ByDr. Brennan Commerford, D.C.·Last reviewed: July 2026

The Evidence-Based Longevity Protocol

A sequenced supplement framework built around hallmarks of aging — NAD+ restoration, senescent cell clearance, autophagy induction, and mitochondrial support.

The ingredients in this pathway are dietary supplements intended to support normal structure and function of the body. They are not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Talk with your healthcare provider before starting any new supplement, especially if you take medications or have a medical condition.

Your Step-by-Step Pathway

  1. 1
    NAD+ restoration: the foundation of cellular longevity
    Pillar Guide

    Research suggests NAD+ levels decline with age (PMID: 24360282, 33353981), a shift linked to DNA repair, sirtuin activity, and mitochondrial function. This pillar guide covers NMN vs NR, dosing research, and bioavailability differences.

  2. 2
    Senescent cell management with fisetin
    Pillar Guide

    Senescent cells accumulate with age and release pro-inflammatory signals (SASP). In a 2018 study in aged mice (PMID 30279143), fisetin was shown to reduce senescent-cell markers across multiple tissues and extend lifespan; this is preclinical (animal) evidence, and whether it translates to humans is not yet established. Fisetin may help support the body's normal cellular-housekeeping processes. This guide covers the evidence quality, study designs, and how researchers have studied senolytic compounds.

  3. 3
    Autophagy vs mitophagy: which matters more?
    Form Comparison

    Spermidine and Urolithin A are studied for their potential roles in autophagy (cellular recycling) and mitophagy (clearance of dysfunctional mitochondria), respectively. This comparison breaks down how researchers describe these pathways and the evidence behind each compound so you can weigh them.

  4. 4
    Magnesium: the cofactor behind 300+ enzymes
    Pillar Guide

    Magnesium is a cofactor involved in over 300 enzymatic reactions, including ATP synthesis and DNA repair. This pillar guide covers how magnesium form affects absorption and why many supplements use lower-absorption forms.

  5. 5
    CoQ10 for mitochondrial electron transport
    Form Comparison

    Ubiquinol vs ubiquinone is one of the most consequential form decisions in longevity supplementation. This comparison covers the conversion efficiency debate, age-related decline in CoQ10, and which form to prioritize.

  6. 6
    The complete longevity ingredient stack
    Condition Hub

    This condition hub assembles the full longevity stack — NAD precursors, senolytics, autophagy activators, and mitochondrial support — ranked by evidence quality and bioavailability tier.

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Related Pathways

The Caloric-Restriction Supplement Support Pathway

A step-by-step supplement framework for people navigating reduced food intake and rapid weight change — covering muscle preservation, micronutrient gaps, and metabolic support.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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