The Evidence-Based Longevity Protocol

NAD+ declines roughly 50% between ages 40 and 60, impairing DNA repair, sirtuin activity, and mitochondrial function. This pillar guide covers NMN vs NR, dosing research, and bioavailability differences.

Senescent cells accumulate with age and release pro-inflammatory signals (SASP). Senolytics like fisetin and quercetin selectively clear these cells. This guide covers the evidence, dosing schedules, and stacking strategies.

Spermidine activates general autophagy (cellular recycling), while Urolithin A specifically targets mitophagy (dysfunctional mitochondria clearance). This comparison breaks down the mechanisms and helps you prioritize.

Magnesium is involved in over 300 enzymatic reactions including ATP synthesis, DNA repair, and sirtuin activation — all central to longevity biology. Most longevity protocols under-dose or use low-bioavailability forms.

Ubiquinol vs ubiquinone is one of the most consequential form decisions in longevity supplementation. This comparison covers the conversion efficiency debate, age-related decline in CoQ10, and which form to prioritize.

This condition hub assembles the full longevity stack — NAD precursors, senolytics, autophagy activators, and mitochondrial support — ranked by evidence quality and bioavailability tier.