Best Supplements for Longevity Support

Healthy aging is increasingly studied at the cellular level, where pathways such as NAD+ metabolism, senescent-cell clearance, and mitochondrial function play distinct roles. Research suggests that NAD+ precursors, senolytic compounds, and CoQ10 each support different aspects of cellular maintenance. FormulaForge ranks every ingredient by the bioavailability of available forms so you can select what your body can actually use.

Updated 2026 · Reviewed by Dr. Brennan Commerford, D.C.

Research-Backed Ingredients

Frequently Asked Questions

What supplements are studied for longevity support?

NAD+ precursors (NMN, NR), senolytic compounds (fisetin, quercetin), and CoQ10 (Ubiquinol) are among the most studied ingredients for supporting cellular maintenance during healthy aging. These supplements are not intended to diagnose, treat, cure, or prevent any disease or to extend lifespan in humans. Consult a qualified healthcare provider before starting any longevity-focused regimen.

Do NAD+ levels change with age?

Research suggests NAD+ levels decline with age, a shift associated with DNA repair, sirtuin activity, and mitochondrial function (Gomes et al. 2013, PMID 24360282; Covarrubias et al. 2021, PMID 33353981). NAD+ precursors such as NMN and NR are studied for their role in supporting NAD+ status. These are structure/function observations — NAD+ supplements are not a treatment for aging or any disease.

What is fisetin studied for?

Fisetin is a flavonoid studied as a senotherapeutic — a compound investigated for its role in clearing senescent cells in preclinical models (Yousefzadeh et al. 2018, PMID 30279143). Human evidence remains early. Fisetin is offered as a structure/function supplement and is not intended to treat any age-related condition.