The Gut Health Formula — Lining, Microbiome & Motility Support
Six ingredients targeting gut lining integrity, microbiome balance, and digestive function — at effective doses based on published clinical data, not label-buffering amounts.
Customize this formulaThe Formula
6 ingredients · 10 capsules/day · Each dose is study-attributed — see citations in line.
Colostrum 25% IgG
A 2017 randomized trial (PMID 28397754, n=16) found bovine colostrum at 500 mg/day decreased intestinal permeability markers (L/M ratio and stool zonulin) in athletes during peak training; the 25% IgG standardization ensures consistent immunoglobulin content for mucosal immune support. (PMID 28397754)
Zinc Carnosine
A 2007 controlled study (PMID 16777920, n=10) found zinc carnosine at 75 mg/day stabilized gut permeability during an indomethacin challenge in healthy volunteers; the carnosine-zinc chelate is specifically studied for gastric lining integrity and is not equivalent to standalone zinc or carnosine. (PMID 16777920)
Bacillus coagulans (200 Billion CFU/G)
A 2023 randomized trial (PMID 36862903, n=70) found B. coagulans 2 billion spores/day significantly reduced indigestion scores (GSRS) including gas and bloating over 4 weeks; B. coagulans spores are heat-stable and acid-resistant, surviving stomach acid to reach the intestines. (PMID 36862903)
Amylase (Food Grade)
Provisional — dose pending confirmationAmylase is included for carbohydrate digestion support; the specific activity-unit dose is pending supplier specification confirmation. This ingredient is listed as provisional — efficacy claims for a specific dose cannot be made until the activity-unit value is confirmed.
Dihydroberberine
A 2021 pharmacokinetic study (PMID 35010998) found dihydroberberine achieves higher plasma absorption compared to berberine, suggesting improved bioavailability of the berberine class; this form is selected for that absorption profile. Further research is needed to confirm GI-specific benefits at this dose. (PMID 35010998)
Magnesium (as DiMagnesium Malate)
DiMagnesium malate provides highly bioavailable elemental magnesium via the malate carrier — better absorbed than magnesium oxide (approximately 4% fractional absorption for oxide, PMID 11794633); magnesium supports smooth muscle function throughout the GI tract. (PMID 11794633)
Why One Formula Beats the Stack
Sourcing these ingredients separately requires 6 bottles and 19 pills per day — vs. 10 capsules in this formula.
19
pills/day (separate bottles)
10
capsules/day (this formula)
Form Quality Gaps
The commodity versions most single-ingredient bottles use — and why they fall short.
| FormulaForge Form | Commodity Default | What the Research Shows |
|---|---|---|
| Zinc Carnosine at 75 mg | Standard zinc (bisglycinate or oxide) | A 2007 randomized trial (PMID 16777920) found that mucosal protective effects are specific to the zinc-carnosine chelate at 75 mg/day — not standalone zinc or carnosine. The two compounds must be chelated together to exhibit the gastric lining support activity shown in the trial. |
| Dihydroberberine (more bioavailable form) | Berberine HCl | A 2021 pharmacokinetics study (PMID 35010998) confirmed dihydroberberine achieves superior plasma absorption compared to berberine HCl; standard berberine HCl has poor oral bioavailability that limits gut-level efficacy.See the evidence → |
| Bacillus coagulans (spore-forming, acid-resistant) | Lactobacillus acidophilus (acid-sensitive) | B. coagulans spores survive gastric acid to reach the intestines where they germinate (PMID 36862903); L. acidophilus and many common probiotic strains are acid-sensitive and show significant viability loss in the stomach before reaching the colon. |
Pricing context
Six separate gut supplements from quality brands typically cost $80–$110/month. This formula's live quote typically comes in at or below that range — with Zinc Carnosine and Colostrum 25% IgG that most budget gut formulas omit entirely.
Exact pricing is quoted live in the builder based on your personalized formula. Example figures are illustrative only and reflect in-one example market research — not a guaranteed price or saving.
This is a starter — you customize it
Every ingredient and dose is adjustable. Add ingredients, swap forms, change doses, or remove anything that doesn't fit your situation. The builder gives you a live price quote as you go.
Frequently Asked Questions
Why is the Amylase dose listed as 'pending'?
Digestive enzyme doses are measured in activity units (e.g., DU for amylase), not milligrams. The specific activity-unit dose depends on the supplier's specification for this batch. Until that value is confirmed, we cannot attach a meaningful efficacy claim to this ingredient. It is listed in the formula as a placeholder — we will update the dose when confirmed.
Is colostrum from bovine sources appropriate for adults?
Yes. Bovine colostrum is used in adults in multiple randomized trials, including a 2017 study (PMID 28397754) in athletes. It is rich in IgG immunoglobulins and growth factors. If you have a dairy sensitivity, consult your physician before use.
How is this different from a standard probiotic supplement?
Most probiotic supplements contain only bacteria — no gut lining support, no zinc carnosine for mucosal integrity, no berberine-class motility support. This formula combines gut lining (colostrum + zinc carnosine), microbiome (B. coagulans), motility (dihydroberberine + magnesium malate), and digestion (amylase) in one stack.
Can I take this formula with food?
Generally yes. Colostrum and zinc carnosine are often better tolerated with food. B. coagulans as a spore-forming probiotic is stable regardless of food timing. Consult your physician for timing guidance specific to your digestive condition.