ByDr. Brennan Commerford, D.C.·Last reviewed: April 2026

Ingredient Guides

Deep-dive research guides, one ingredient at a time. Each guide walks through the forms that ingredient comes in, how those forms differ, and what the published literature reports — with the studies cited so you can read them yourself.

These guides summarize peer-reviewed research on ingredient forms, absorption, and dosing. Statements attributed to studies reflect published findings; individual responses vary. Consult your physician before changing any supplement regimen.

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GuideCreatine

A research-backed guide to creatine — forms (Monohydrate, HCl, and more), ATP regeneration, loading protocols, cognitive benefits, and evidence-based dosing guidance.

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GuideVitamin D3

Why D3 is more effective than D2, the role of K2 and magnesium cofactors, calcidiol for absorption challenges, and how to dose by serum level.

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GuideBerberine

A complete guide to berberine forms — standard HCl and dihydroberberine — bioavailability, AMPK activation, GI tolerability, and how form selection determines metabolic support efficacy.

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GuideAshwagandha

A complete guide to ashwagandha extracts — KSM-66, Sensoril, Shoden, and root powder. Withanolide content, cortisol modulation, and evidence-based dosing for stress and performance.

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GuideInositol

What the research on inositol and PCOS shows — the 40:1 myo to D-chiro ratio, insulin signaling, ovarian function, and how to combine with berberine for metabolic support.

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GuideNAD+ Precursors

A research-backed guide to NAD+ precursors (NMN and NR) — cellular energy, DNA repair, sirtuin activation, the 2026 head-to-head trial results, dosing protocols, epigenetic aging markers, and safety profile.

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GuideSenolytics

A practitioner's evidence review of natural senolytics — fisetin, quercetin, cyclical dosing protocols, the SASP mechanism, and an honest assessment of what the current science does and does not support.

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GuideMagnesium

A research-backed comparison of 8 magnesium forms — glycinate, L-threonate, citrate, oxide, malate, taurate, orotate, and topical forms — covering bioavailability, elemental content, use cases, and how to choose by health goal.

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GuideCoQ10

A research-backed guide to CoQ10 forms — Ubiquinol and Ubiquinone — statin depletion, aging decline, heart health, dosing, and why form matters after 40.

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GuideOmega-3

A complete guide to omega-3 forms — triglyceride and ethyl ester fish oil absorption differences, rancidity testing, EPA vs DHA by goal, and REDUCE-IT evidence explained.

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GuideSelenium

Selenium bioavailability varies between forms. As an NTI mineral, form selection is a safety decision. Compare selenomethionine, selenium yeast, selenite, selenate, and methylselenocysteine with pharmacokinetic data and 0-100 scores.

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GuideIron

Iron bioavailability varies between forms, and GI tolerability varies even more. Compare bisglycinate, ferrous sulfate, heme iron, and more — with head-to-head clinical data and 0-100 scores.

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GuideZinc

Zinc bioavailability varies between forms. Compare picolinate, bisglycinate, oxide, gluconate, carnosine, and acetate — with absorption data, immune evidence, copper balance guidance, and 0-100 scores.

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GuideAlpha-Lipoic Acid

A research-backed guide to alpha-lipoic acid — R-ALA and racemic forms, dual-phase antioxidant mechanisms, mitochondrial cofactor roles, dosing guidance, and why enantiomer selection determines both efficacy and tolerability.

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GuideAstaxanthin

A research-backed guide to astaxanthin — natural Haematococcus pluvialis vs synthetic forms, skin elasticity and eye fatigue evidence, lipid-based absorption optimization, and evidence-based dosing.

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GuideL-Theanine

A research-backed guide to L-theanine — alpha-wave mechanisms, stress response attenuation, the L-theanine + caffeine combination evidence, sleep quality support, and dosing guidance for calm focus without sedation.

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