ByDr. Brennan Commerford, D.C.·Last reviewed: May 2026

Supplement Deep Dives (2026)

Evidence-based, long-form ingredient research. Each guide covers mechanisms, bioavailability, forms, dosing, and safety — written for practitioners and informed consumers.

Deep Dive

Berberine

A research-backed comparison of Berberine HCl vs Dihydroberberine — absorption scores, AMPK activation, dosing guidance, and why form matters for bioavailability.

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Deep Dive

Creatine

Creatine Monohydrate vs HCl — ATP regeneration, loading protocols, cognitive benefits, dosing, and why monohydrate remains the gold standard.

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Deep Dive

Vitamin D3

A research-backed guide to Vitamin D3 vs D2 — bioavailability scores, calcidiol advantages, K2 and magnesium cofactors, dosing by deficiency level, and why sun exposure alone is not enough.

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Deep Dive

Ashwagandha

A research-backed comparison of KSM-66, Sensoril, and Shoden ashwagandha extracts — withanolide content, cortisol research, dosing guidance, thyroid considerations, and FormulaForge bioavailability scores.

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Deep Dive

Inositol

Myo-inositol and D-chiro-inositol guide — the 40:1 ratio, insulin signaling mechanisms, berberine combinations, and dosing for metabolic support.

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Deep Dive

Magnesium

A research-backed comparison of 8 magnesium forms — glycinate, L-threonate, citrate, oxide, malate, taurate, orotate, and topical forms — covering bioavailability, elemental content, use cases, and how to choose by health goal.

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Deep Dive

CoQ10

Ubiquinol vs Ubiquinone: research-backed comparison, statin depletion, aging decline, heart health, dosing, and why form matters after 40.

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Deep Dive

Omega-3

Triglyceride vs ethyl ester fish oil: absorption differences, rancidity testing, EPA vs DHA by goal, and REDUCE-IT evidence explained.

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Deep Dive

NAD+ Precursors

A research-backed comparison of NMN vs NR for NAD+ elevation — cellular energy, DNA repair, sirtuin activation, the 2026 head-to-head trial results, dosing protocols, epigenetic aging markers, and safety profile.

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Deep Dive

Senolytics

A practitioner's evidence review of natural senolytics — fisetin, quercetin, cyclical dosing protocols, the SASP mechanism, and an honest assessment of what the current science does and does not support.

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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.