Vitamin K2 (as Menaquinone-7)

Vitamin K2 (as Menaquinone-7) is a Vitamin supplement available in 1 form.

Not all forms of Vitamin K2 (as Menaquinone-7) are equal. The form you choose determines how much Vitamin K2 (as Menaquinone-7) actually reaches your tissues, and the difference between the best and worst forms can be substantial. MK-7 has a 72-hour half-life vs 1-2 hours for MK-4, enabling once-daily dosing with sustained tissue-level activity. Clinical trials demonstrate MK-7 superiority for osteocalcin carboxylation (bone health marker) and matrix Gla-protein activation (arterial calcification prevention) at doses as low as 180mcg/day.

Vitamin K2 (as MK-7) Preferred (T1 Preferred) has a bioavailability rating of high (S1 — best tier). Typical dose range: not yet documented in our database.

Menaquinone-7 (MK-7) is the most bioactive form of vitamin K2, with a significantly longer half-life (72 hours) compared to MK-4 (1-2 hours). This allows for once-daily dosing with sustained tissue-level activity. Multiple clinical studies support MK-7 for bone mineral density maintenance and cardiovascular health, particularly in combination with vitamin D3 and calcium.

PMID: 23140417

Vitamin K2 (as MK-7) is classified as T1 Preferred in the FormulaForge formulary — our top recommendation for Vitamin K2 (as Menaquinone-7). It carries a bioavailability rating of high (S1 — best tier), meaning more of the active compound reaches your tissues per dose unit compared to lower-tier forms.

When choosing a Vitamin K2 (as Menaquinone-7) supplement, look for the S1 (best absorption) bioavailability tier on the label or formulary listing. T1 Preferred forms have the strongest research-backed evidence for efficient absorption.

Other forms may be appropriate depending on individual goals, cost considerations, and your healthcare provider’s guidance. The best form for you depends on your specific health needs.

For Vitamin K2 (as MK-7), the typical dosing range is not yet documented in our database. Individual dose requirements vary based on health goals, body weight, and existing nutrient intake.

Side Effects: Specific side effect data for these forms is not yet documented in our database. In general, consult your healthcare provider regarding tolerability at higher doses.

These statements are based on structure/function research and have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before starting or changing a supplement regimen.

The following studies and findings inform our formulary classifications for Vitamin K2 (as Menaquinone-7):

PMID: 23140417