Vitamin K1

Vitamin K1 is a Vitamin supplement available in 1 form.

Not all forms of Vitamin K1 are equal. The form you choose determines how much Vitamin K1 actually reaches your tissues, and the difference between the best and worst forms can be substantial. Vitamin K1 (phylloquinone) is the dietary form of vitamin K found in green leafy vegetables that primarily supports hepatic coagulation factor synthesis. Research supports vitamin K1 for promoting healthy blood coagulation protein activation and bone osteocalcin activity, serving as a foundational K vitamin alongside K2 forms.

Vitamin K1 (Secondary Form) has a bioavailability rating of good absorption.

Vitamin K1 (phylloquinone) is the primary dietary form of vitamin K, predominantly found in green leafy vegetables. It is the form most directly involved in hepatic synthesis of clotting factors. While MK-7 has superior extrahepatic activity, K1 remains clinically important for individuals on anticoagulant therapy requiring precise dosing management.

Human Phase-I PK: oral phylloquinone (vitamin K1) mixed-micelle pharmacokinetics; VKORC1-genotype dependent. PMID: 22864379

Human: supplemental phylloquinone (vitamin K1) bioavailability higher than from food (raw spinach). PMID: 10356087

Multiple forms of Vitamin K1 are available. Start by comparing form ratings — Preferred Forms reflect the strongest bioavailability evidence, and higher-absorption forms deliver more active compound per dose unit.

The appropriate form depends on your individual goals and your healthcare provider’s recommendations. Consult a qualified professional before selecting a supplement form.

Individual dose requirements vary based on health goals, body weight, and existing nutrient intake. Your healthcare provider can help you determine an appropriate amount of Vitamin K1 for you.

Side Effects: Consult your healthcare provider regarding tolerability, particularly at higher doses.

These statements are based on structure/function research and have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before starting or changing a supplement regimen.

The following studies and findings inform FormulaForge classifications for Vitamin K1:

Human Phase-I PK: oral phylloquinone (vitamin K1) mixed-micelle pharmacokinetics; VKORC1-genotype dependent. PMID: 22864379

Human: supplemental phylloquinone (vitamin K1) bioavailability higher than from food (raw spinach). PMID: 10356087