Urolithin A

Urolithin A is a Specialty supplement available in 1 form.

Not all forms of Urolithin A are equal. The form you choose determines how much Urolithin A actually reaches your tissues, and the difference between the best and worst forms can be substantial. Urolithin A is a gut microbiome metabolite of ellagitannins (from pomegranate and berries) that directly activates mitophagy—the selective removal of damaged mitochondria. As a pure, bioavailable form, research supports urolithin A for promoting healthy mitochondrial quality control and muscle function, particularly for individuals whose gut microbiome cannot efficiently produce it from dietary precursors.

Urolithin A Preferred (Preferred Form) has a bioavailability rating of good absorption.

Urolithin A is a postbiotic metabolite that activates mitophagy — the selective cleanup of damaged mitochondria. Only ~40% of people produce adequate urolithin A from dietary pomegranate, making direct supplementation valuable. Clinical trials demonstrate improved mitochondrial function, muscle endurance, and cellular aging biomarkers. It is the first clinically validated mitophagy activator.

Oral urolithin A supplement raised plasma UA concentrations >6-fold at 1h in healthy adults; form-specific supplement absorption confirmed PMID: 34117375

Urolithin A is orally bioavailable and may support normal mitochondrial function in older adults. In a first-in-human clinical trial in healthy sedentary older adults, urolithin A was bioavailable at all doses and modulated markers of mitochondrial health. PMID: 32694802

Urolithin A may support recovery from strenuous exercise in healthy, trained adults. In a randomized double-blind trial of 42 trained male distance runners, urolithin A lowered perceived exertion and markers of post-exercise muscle damage — though running performance itself was not significantly improved. PMID: 40839339

Urolithin A is classified as Preferred Form by FormulaForge — our top recommendation for Urolithin A. It carries a bioavailability rating of good absorption, meaning more of the active compound reaches your tissues per dose unit compared to lower-rated forms.

When choosing a Urolithin A supplement, read the label for the specific form name — that is what determines how much you actually absorb. Preferred Forms have the strongest research-backed evidence for efficient absorption.

Other forms may be appropriate depending on individual goals, cost considerations, and your healthcare provider’s guidance. The best form for you depends on your specific health needs.

Individual dose requirements vary based on health goals, body weight, and existing nutrient intake. Your healthcare provider can help you determine an appropriate amount of Urolithin A for you.

Side Effects: Consult your healthcare provider regarding tolerability, particularly at higher doses.

These statements are based on structure/function research and have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before starting or changing a supplement regimen.

The following studies and findings inform FormulaForge classifications for Urolithin A:

Oral urolithin A supplement raised plasma UA concentrations >6-fold at 1h in healthy adults; form-specific supplement absorption confirmed PMID: 34117375

Urolithin A is orally bioavailable and may support normal mitochondrial function in older adults. In a first-in-human clinical trial in healthy sedentary older adults, urolithin A was bioavailable at all doses and modulated markers of mitochondrial health. PMID: 32694802

Urolithin A may support recovery from strenuous exercise in healthy, trained adults. In a randomized double-blind trial of 42 trained male distance runners, urolithin A lowered perceived exertion and markers of post-exercise muscle damage — though running performance itself was not significantly improved. PMID: 40839339