Shiitake

Shiitake is a Specialty supplement available in 1 form.

Not all forms of Shiitake are equal. The form you choose determines how much Shiitake actually reaches your tissues, and the difference between the best and worst forms can be substantial. This standardized Shiitake (Lentinula edodes) mushroom extract concentrates the beta-glucans and lentinan polysaccharides responsible for immune modulation. Research supports shiitake extract for promoting healthy NK cell activity, immune response, and cardiovascular function compared to whole dried mushroom powder with variable polysaccharide content.

Shiitake Preferred (Preferred Form) has a bioavailability rating of good (S2). Typical dose range: not yet documented in our database.

Shiitake (Lentinula edodes) extract provides lentinan — a beta-glucan with extensive clinical research for immune modulation. Research demonstrates enhanced NK cell activity, macrophage activation, and cytokine balance. Shiitake is also one of the few natural dietary sources of ergosterol (provitamin D2), supporting vitamin D status alongside immune function.

Shiitake is classified as Preferred Form by FormulaForge — our top recommendation for Shiitake. It carries a bioavailability rating of good (S2), meaning more of the active compound reaches your tissues per dose unit compared to lower-rated forms.

When choosing a Shiitake supplement, look for the S1 (best absorption) bioavailability tier on the label. Preferred Forms have the strongest research-backed evidence for efficient absorption.

Other forms may be appropriate depending on individual goals, cost considerations, and your healthcare provider’s guidance. The best form for you depends on your specific health needs.

For Shiitake, the typical dosing range is not yet documented in our database. Individual dose requirements vary based on health goals, body weight, and existing nutrient intake.

Side Effects: Specific side effect data for these forms is not yet documented in our database. In general, consult your healthcare provider regarding tolerability at higher doses.

These statements are based on structure/function research and have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before starting or changing a supplement regimen.