Rhodiola

Rhodiola is a Botanical supplement available in 1 form.

Not all forms of Rhodiola are equal. The form you choose determines how much Rhodiola actually reaches your tissues, and the difference between the best and worst forms can be substantial. Standardized Rhodiola rosea extract is the preferred adaptogenic form, concentrated for rosavins and salidroside—the active compounds with documented effects on HPA axis regulation and stress adaptation. Research supports standardized-ratio rhodiola extracts (3:1 rosavin:salidroside) for promoting healthy cognitive performance, fatigue resistance, and cortisol balance.

Rhodiola (Rhodiola rosea) Root Extract (4% Rosavins, 1% Salidroside) Preferred (Preferred Form) has a bioavailability rating of good absorption. Typical dose range: not yet documented in our database.

Rhodiola rosea standardized extract provides rosavins and salidroside — adaptogens that modulate cortisol, enhance ATP regeneration, and support neurotransmitter balance. Clinical trials demonstrate benefits for physical endurance, cognitive performance under stress, and fatigue reduction. It is one of the most evidence-backed adaptogens with a strong safety profile.

Phase III double-blind RCT (n=60); standardized SHR-5 Rhodiola rosea extract reduced burnout and cortisol awakening response in stress-related fatigue. PMID: 19016404

Double-blind crossover RCT (n=56 physicians); standardized SHR-5 extract improved a mental-fatigue index during night duty vs placebo. PMID: 11081987

Parallel-group RCT (n=161 cadets); standardized SHR-5 extract significantly raised an anti-fatigue index vs placebo. PMID: 12725561

Rhodiola (Rhodiola rosea) Root Extract (4% Rosavins, 1% Salidroside) is classified as Preferred Form by FormulaForge — our top recommendation for Rhodiola. It carries a bioavailability rating of good absorption, meaning more of the active compound reaches your tissues per dose unit compared to lower-rated forms.

When choosing a Rhodiola supplement, look for the S1 (best absorption) bioavailability tier on the label. Preferred Forms have the strongest research-backed evidence for efficient absorption.

Other forms may be appropriate depending on individual goals, cost considerations, and your healthcare provider’s guidance. The best form for you depends on your specific health needs.

For Rhodiola (Rhodiola rosea) Root Extract (4% Rosavins, 1% Salidroside), the typical dosing range is not yet documented in our database. Individual dose requirements vary based on health goals, body weight, and existing nutrient intake.

Side Effects: Specific side effect data for these forms is not yet documented in our database. In general, consult your healthcare provider regarding tolerability at higher doses.

These statements are based on structure/function research and have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before starting or changing a supplement regimen.

The following studies and findings inform FormulaForge classifications for Rhodiola:

Phase III double-blind RCT (n=60); standardized SHR-5 Rhodiola rosea extract reduced burnout and cortisol awakening response in stress-related fatigue. PMID: 19016404

Double-blind crossover RCT (n=56 physicians); standardized SHR-5 extract improved a mental-fatigue index during night duty vs placebo. PMID: 11081987

Parallel-group RCT (n=161 cadets); standardized SHR-5 extract significantly raised an anti-fatigue index vs placebo. PMID: 12725561