Phosphatidylserine

Phosphatidylserine is a Lipid supplement available in 1 form.

Not all forms of Phosphatidylserine are equal. The form you choose determines how much Phosphatidylserine actually reaches your tissues, and the difference between the best and worst forms can be substantial. Soy-derived phosphatidylserine is the most clinically researched phospholipid for cognitive applications, with FDA-qualified health claim status for its relationship to cognitive function. As an S1-tier compound, research demonstrates that soy-sourced phosphatidylserine supports healthy cortisol response, memory recall, and neuronal membrane fluidity.

Phosphatidylserine Preferred (Preferred Form) has a bioavailability rating of high absorption.

Phosphatidylserine (PS) is a phospholipid concentrated in brain cell membranes, essential for neurotransmitter release and synaptic function. Clinical trials demonstrate benefits for memory, attention, and cortisol management during stress. The FDA permits a qualified health claim linking PS to reduced risk of cognitive decline. Soy-derived PS provides identical molecular structure to endogenous PS.

Placebo-controlled RCT (n=75 men); soy-based PS/PA complex normalized HPA-axis (ACTH, cortisol) stress reactivity in chronically stressed subjects. PMID: 25081826

Controlled trial (n=120 elderly); soy-derived phosphatidylserine 300/600 mg/day was well tolerated (memory endpoints null) — establishes the modern non-bovine soy-PS form. PMID: 11842880

Double-blind RCT (n=36 children); soy-derived phosphatidylserine 200 mg/day improved ADHD symptoms and short-term auditory memory vs placebo. PMID: 23495677

Phosphatidylserine is classified as Preferred Form by FormulaForge — our top recommendation for Phosphatidylserine. It carries a bioavailability rating of high absorption, meaning more of the active compound reaches your tissues per dose unit compared to lower-rated forms.

When choosing a Phosphatidylserine supplement, read the label for the specific form name — that is what determines how much you actually absorb. Preferred Forms have the strongest research-backed evidence for efficient absorption.

Other forms may be appropriate depending on individual goals, cost considerations, and your healthcare provider’s guidance. The best form for you depends on your specific health needs.

Individual dose requirements vary based on health goals, body weight, and existing nutrient intake. Your healthcare provider can help you determine an appropriate amount of Phosphatidylserine for you.

Side Effects: Consult your healthcare provider regarding tolerability, particularly at higher doses.

These statements are based on structure/function research and have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before starting or changing a supplement regimen.

The following studies and findings inform FormulaForge classifications for Phosphatidylserine:

Placebo-controlled RCT (n=75 men); soy-based PS/PA complex normalized HPA-axis (ACTH, cortisol) stress reactivity in chronically stressed subjects. PMID: 25081826

Controlled trial (n=120 elderly); soy-derived phosphatidylserine 300/600 mg/day was well tolerated (memory endpoints null) — establishes the modern non-bovine soy-PS form. PMID: 11842880

Double-blind RCT (n=36 children); soy-derived phosphatidylserine 200 mg/day improved ADHD symptoms and short-term auditory memory vs placebo. PMID: 23495677