ByDr. Brennan Commerford, Chiropractic Physician·Last reviewed: April 2026
All Ingredients
Botanical1 form

Licorice Root Extract

Preferred Form
Glycyrrhizic Acid 20%
Bioavailability
S2
Evidence Level
Moderate Evidence

Quick Answer

What is the best form of Licorice Root Extract?

Glycyrrhizic Acid 20% is our top-ranked form of Licorice Root Extract, classified as T1 Preferred with S2 bioavailability. We compared 1 forms in our formulary.

Our recommendation: Glycyrrhizic Acid 20%

1forms compared

All Forms of Licorice Root Extract

FormTierBioavailabilityDose RangeUnit
Glycyrrhizic Acid 20%T1 PreferredS2

Bioavailability by Form

S2 — Good
Glycyrrhizic Acid 20%

What is Licorice Root Extract?

Licorice Root Extract is a Botanical supplement available in 1 form.

Not all forms of Licorice Root Extract are equal. The form you choose determines how much Licorice Root Extract actually reaches your tissues, and the difference between the best and worst forms can be substantial. Licorice root extract standardized to 20% glycyrrhizic acid provides consistent potency of the primary saponin that supports healthy cortisol metabolism and mucosal integrity. Research suggests this standardized form promotes healthy adrenal function and gastrointestinal mucosal health with predictable glycyrrhizinic acid delivery.

Forms of Licorice Root Extract Compared

Licorice (Glycyrrhiza glabra) Root Extract (20% Glycyrrhizic Acid) Preferred (T1 Preferred) has a bioavailability rating of good (S2). Typical dose range: not yet documented in our database.

What the Research Shows

Licorice root extract standardized to 20% glycyrrhizic acid provides the bioactive triterpene saponin responsible for adrenal and digestive support. Research demonstrates cortisol-sparing effects via 11-beta-HSD2 enzyme inhibition. Note: prolonged high-dose use requires monitoring due to potential mineralocorticoid effects on blood pressure and potassium levels.

How to Choose the Right Form

Licorice (Glycyrrhiza glabra) Root Extract (20% Glycyrrhizic Acid) is classified as T1 Preferred in the FormulaForge formulary — our top recommendation for Licorice Root Extract. It carries a bioavailability rating of good (S2), meaning more of the active compound reaches your tissues per dose unit compared to lower-tier forms.

When choosing a Licorice Root Extract supplement, look for the S1 (best absorption) bioavailability tier on the label or formulary listing. T1 Preferred forms have the strongest research-backed evidence for efficient absorption.

Other forms may be appropriate depending on individual goals, cost considerations, and your healthcare provider’s guidance. The best form for you depends on your specific health needs.

Dosing & Safety

For Licorice (Glycyrrhiza glabra) Root Extract (20% Glycyrrhizic Acid), the typical dosing range is not yet documented in our database. Individual dose requirements vary based on health goals, body weight, and existing nutrient intake.

Side Effects: Specific side effect data for these forms is not yet documented in our database. In general, consult your healthcare provider regarding tolerability at higher doses.

These statements are based on structure/function research and have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before starting or changing a supplement regimen.

Dosing Guidance

Dosing information not yet available for this ingredient.

Frequently Asked Questions

What is the best form of Licorice Root Extract?
Licorice (Glycyrrhiza glabra) Root Extract (20% Glycyrrhizic Acid) is the T1 Preferred form of Licorice Root Extract in the FormulaForge formulary, reflecting research-backed evidence for superior bioavailability (good (S2)). This classification is based on published absorption studies and clinical evidence quality. The best form for you depends on your individual health goals and your healthcare provider's recommendations. Always consult a qualified healthcare provider before starting, stopping, or adjusting any supplement regimen.
How much Licorice Root Extract should I take daily?
Dosing information for Licorice Root Extract is being compiled in our database. Individual dose requirements vary based on health goals and existing nutrient intake. Always consult a qualified healthcare provider before starting, stopping, or adjusting any supplement regimen. These statements are based on structure/function research and have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease.
What are the benefits of Licorice Root Extract?
Licorice Root Extract has been studied for its role in supporting: Supports adrenal health and healthy cortisol levels, Supports digestive comfort and gut lining integrity, Supports respiratory health, Supports immune system function. Licorice root extract standardized to 20% glycyrrhizic acid provides the bioactive triterpene saponin responsible for adrenal and digestive support. Research demonstrates cortisol-sparing effects via 11-beta-HSD2 enzyme inhibition. Note: prolonged high-dose use requires monitoring due to potential mineralocorticoid effects on blood pressure and potassium levels. These statements are based on structure/function research and have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease.
When is the best time to take Licorice Root Extract?
Optimal timing for Licorice Root Extract supplementation depends on the specific form, dosage, and individual factors. Some forms may be better absorbed with food; others may not require food. Always consult a qualified healthcare provider before starting, stopping, or adjusting any supplement regimen.
Are there side effects of taking Licorice Root Extract?
Tolerability of this Botanical supplement varies by individual, dose, and specific form. Some individuals may experience gastrointestinal discomfort at higher doses. Specific side effect profiles for each form of Licorice Root Extract are documented in our formulary where available. Always consult a qualified healthcare provider before starting, stopping, or adjusting any supplement regimen. These statements are based on structure/function research and have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease.
What forms of Licorice Root Extract are available?
There are 1 form of Licorice Root Extract in our formulary: Licorice (Glycyrrhiza glabra) Root Extract (20% Glycyrrhizic Acid) (T1 Preferred, bioavailability: good (S2)). Forms differ in chemical structure, bioavailability, and typical dose range. FormulaForge classifies forms by tier based on published bioavailability evidence.

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Our formulary recommends Glycyrrhizic Acid 20% for optimal bioavailability. Build your personalized formula now.

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FormulaForge formulates and sells supplements containing the ingredients discussed on this page. Our formulary recommendations are based on peer-reviewed bioavailability research. All cited studies are independently verifiable.