Folic Acid

Folic Acid is a Vitamin supplement available in 1 form.

FormulaForge carries a single form of Folic Acid, so there is no form to choose here. Forms on the market do differ in how well they absorb, which is why it is worth checking the form named on any product label.

Folic Acid (Mapped Form) has a bioavailability rating of lower absorption.

**Folic acid** (vitamin B9) supplementation has well-established clinical benefits, safety profile, dosing guidelines, and bioavailability characteristics supported by extensive research, including recent studies up to 2023-2024.

Randomised crossover, n=24 healthy adults, EQUIMOLAR single dose (Na-5-MTHF 436 mcg vs folic acid 400 mcg, 0.906 umol each). Plasma 5-MTHF AUC0-8h 126.0+/-33.6 vs 56.0+/-25.3 nmol/L*h (ratio 2.25x); Cmax ratio 3.31x. SINGLE-DOSE PLASMA AUC - not the endpoint this DCR uses. PMID: 33255787

Regulatory synthesis of multiple RCTs: RBC folate 23% higher (95% CI 11-37%) for L-5-MTHF vs folic acid at >=400 mcg/day, chronic dosing. THE BASIS OF THIS DCR. EFSA also treats the calcium and glucosamine salts as bioequivalent per mg of active 5-MTHF, citing an UNPUBLISHED 2010 crossover (n=24) - that salt-parity claim is UNVERIFIED. DOI: 10.2903/j.efsa.2022.7452

Narrative review. States folic acid and L-5-MTHF are comparable at EQUIMOLAR doses (reads ~1:1). Directional support only - a review, not a ratio source. Mass-corrected this would give ~1.04, which is direction-illegal for S4->S1. PMID: 20608755

Multiple forms of Folic Acid are available. Start by comparing form ratings — Preferred Forms reflect the strongest bioavailability evidence, and higher-absorption forms deliver more active compound per dose unit.

The appropriate form depends on your individual goals and your healthcare provider’s recommendations. Consult a qualified professional before selecting a supplement form.

Individual dose requirements vary based on health goals, body weight, and existing nutrient intake. Your healthcare provider can help you determine an appropriate amount of Folic Acid for you.

Side Effects: Consult your healthcare provider regarding tolerability, particularly at higher doses.

These statements are based on structure/function research and have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before starting or changing a supplement regimen.

The following studies and findings inform FormulaForge classifications for Folic Acid:

Randomised crossover, n=24 healthy adults, EQUIMOLAR single dose (Na-5-MTHF 436 mcg vs folic acid 400 mcg, 0.906 umol each). Plasma 5-MTHF AUC0-8h 126.0+/-33.6 vs 56.0+/-25.3 nmol/L*h (ratio 2.25x); Cmax ratio 3.31x. SINGLE-DOSE PLASMA AUC - not the endpoint this DCR uses. PMID: 33255787

Regulatory synthesis of multiple RCTs: RBC folate 23% higher (95% CI 11-37%) for L-5-MTHF vs folic acid at >=400 mcg/day, chronic dosing. THE BASIS OF THIS DCR. EFSA also treats the calcium and glucosamine salts as bioequivalent per mg of active 5-MTHF, citing an UNPUBLISHED 2010 crossover (n=24) - that salt-parity claim is UNVERIFIED. DOI: 10.2903/j.efsa.2022.7452

Narrative review. States folic acid and L-5-MTHF are comparable at EQUIMOLAR doses (reads ~1:1). Directional support only - a review, not a ratio source. Mass-corrected this would give ~1.04, which is direction-illegal for S4->S1. PMID: 20608755