vitamin1 form

Folate (Quatrefolic 6S-5-MTHF)

Evidence Level

Moderate Evidence

Which Folate (Quatrefolic 6S-5-MTHF) form is best?

See our full ranked comparison — scored by absorption, bioavailability & formulary tier

Quick Answer

What is the best form of Folate (Quatrefolic 6S-5-MTHF)?

We compared 1 forms of Folate (Quatrefolic 6S-5-MTHF) in our formulary. Browse the comparison table below to find the best-absorbed form for your goals and dosing needs.

1forms compared

All Forms of Folate (Quatrefolic 6S-5-MTHF)

Form	Tier	Form Score	Dose Range	Unit
Folate Quatrefolic®	Mapped	100/100Top Tier	—	—

Absorption by Form

Top Tier

Folate Quatrefolic®

100/100

What is Folate (Quatrefolic 6S-5-MTHF)?

Folate (Quatrefolic 6S-5-MTHF) is a vitamin supplement available in 1 form.

Not all forms of Folate (Quatrefolic 6S-5-MTHF) are equal. The form you choose determines how much Folate (Quatrefolic 6S-5-MTHF) actually reaches your tissues, and the difference between the best and worst forms can be substantial. FormulaForge ranks every form by how well it absorbs and how strongly the published research supports it, giving you an evidence-based guide for choosing wisely.

Forms of Folate (Quatrefolic 6S-5-MTHF) Compared

Folate Quatrefolic® (6s)-5-methyltetrahydrofolic acid, glucosamine salt (Mapped Form) has a bioavailability rating of high absorption.

What the Research Shows

Below is a focused, evidence-based summary of Quatrefolic® (the glucosamine salt of (6S)-5-methyltetrahydrofolic acid, often written as (6S)-5-MTHF–glucosamine) covering clinical evidence, benefits, dosing, safety, bioavailability/absorption, interactions, and key 2023–2024 research. Sources referenced are clinical trials, systematic reviews, pharmacokinetic studies, and regulatory/monograph data up to 2024.

Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. PMID: 24494987

Comparative Analysis of Treatment With Folate Forms in Clinical Practice. PMID: 41277701

[6S]5-methyltetrahydrofolate or folic acid supplementation and absorption and initial elimination of folate in young and middle-aged adults. PMID: 16151461

How to Choose the Right Form

Multiple forms of Folate (Quatrefolic 6S-5-MTHF) are available. Start by comparing form ratings — Preferred Forms reflect the strongest bioavailability evidence, and higher-absorption forms deliver more active compound per dose unit.

The appropriate form depends on your individual goals and your healthcare provider’s recommendations. Consult a qualified professional before selecting a supplement form.

Dosing & Safety

Individual dose requirements vary based on health goals, body weight, and existing nutrient intake. Your healthcare provider can help you determine an appropriate amount of Folate (Quatrefolic 6S-5-MTHF) for you.

Side Effects: Consult your healthcare provider regarding tolerability, particularly at higher doses.

These statements are based on structure/function research and have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before starting or changing a supplement regimen.

The Science

The following studies and findings inform FormulaForge classifications for Folate (Quatrefolic 6S-5-MTHF):

Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. PMID: 24494987

Comparative Analysis of Treatment With Folate Forms in Clinical Practice. PMID: 41277701

[6S]5-methyltetrahydrofolate or folic acid supplementation and absorption and initial elimination of folate in young and middle-aged adults. PMID: 16151461

Dosing Guidance

Individual dose requirements for Folate (Quatrefolic 6S-5-MTHF) vary based on health goals, body weight, and existing dietary intake. A qualified healthcare provider can help you determine an appropriate amount for you.

Frequently Asked Questions

What is the best form of Folate (Quatrefolic 6S-5-MTHF)?

Folate (Quatrefolic 6S-5-MTHF) is available in several forms. Focus on products that specify the form on the label — not all forms are equally absorbed by the body.

How much Folate (Quatrefolic 6S-5-MTHF) should I take?

Dosing for Folate (Quatrefolic 6S-5-MTHF) varies based on the specific form, your health goals, and individual factors. Consult a qualified healthcare provider for personalized guidance.

What does Folate (Quatrefolic 6S-5-MTHF) support?

Folate (Quatrefolic 6S-5-MTHF) is commonly used to support vitamin. Research suggests it plays a role in several physiological pathways. As with all supplements, these statements have not been evaluated by the Food and Drug Administration and Folate (Quatrefolic 6S-5-MTHF) is not intended to diagnose, treat, cure, or prevent any disease.

Is Folate (Quatrefolic 6S-5-MTHF) safe?

Folate (Quatrefolic 6S-5-MTHF) is generally well-tolerated when taken at research-supported doses. As with any supplement, individual responses vary. Consult a qualified healthcare provider before use, especially if you are pregnant, nursing, have a medical condition, or take medications. These statements have not been evaluated by the Food and Drug Administration.

Ready to formulate with Folate (Quatrefolic 6S-5-MTHF)?

Build your personalized formula with research-backed dosing.

Start My Formula

Compare & Learn More

All vitamin Ingredients

Compare forms and bioavailability across the vitamin category

References

Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. PubMed DOI
Comparative Analysis of Treatment With Folate Forms in Clinical Practice. PubMed DOI
[6S]5-methyltetrahydrofolate or folic acid supplementation and absorption and initial elimination of folate in young and middle-aged adults. PubMed DOI

FormulaForge formulates and sells supplements containing the ingredients discussed on this page. Our formulary recommendations are based on peer-reviewed bioavailability research. All cited studies are independently verifiable.