ByDr. Brennan Commerford, D.C.·Last reviewed: April 2026
All Ingredients
vitamin1 form

Folate (Quatrefolic 6S-5-MTHF)

Evidence Level
Moderate Evidence

The Folate (Quatrefolic 6S-5-MTHF) form we carry

See how we score it — absorption, bioavailability & formulary tier

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Quick Answer

Which form of Folate (Quatrefolic 6S-5-MTHF) do we use?

Our formulary carries a single form of Folate (Quatrefolic 6S-5-MTHF). See the details below.

All Forms of Folate (Quatrefolic 6S-5-MTHF)

FormTierForm ScoreDose RangeUnit
Folate Quatrefolic®Mapped
100/100Top Tier
——

Absorption by Form

Top Tier
Folate Quatrefolic®
100/100

What is Folate (Quatrefolic 6S-5-MTHF)?

Folate (Quatrefolic 6S-5-MTHF) is a vitamin supplement available in 1 form.

FormulaForge carries a single form of Folate (Quatrefolic 6S-5-MTHF), so there is no form to choose here. Forms on the market do differ in how well they absorb, which is why it is worth checking the form named on any product label.

The Form of Folate (Quatrefolic 6S-5-MTHF) We Carry

Folate Quatrefolic® (6s)-5-methyltetrahydrofolic acid, glucosamine salt (Mapped Form) has a bioavailability rating of high absorption.

How to Choose the Right Form

Multiple forms of Folate (Quatrefolic 6S-5-MTHF) are available. Start by comparing form ratings — Preferred Forms reflect the strongest bioavailability evidence, and higher-absorption forms deliver more active compound per dose unit.

The appropriate form depends on your individual goals and your healthcare provider’s recommendations. Consult a qualified professional before selecting a supplement form.

Dosing & Safety

Individual dose requirements vary based on health goals, body weight, and existing nutrient intake. Your healthcare provider can help you determine an appropriate amount of Folate (Quatrefolic 6S-5-MTHF) for you.

Side Effects: Consult your healthcare provider regarding tolerability, particularly at higher doses.

These statements are based on structure/function research and have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before starting or changing a supplement regimen.

The Science

The following studies and findings inform FormulaForge classifications for Folate (Quatrefolic 6S-5-MTHF):

Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. PMID: 24494987
Comparative Analysis of Treatment With Folate Forms in Clinical Practice. PMID: 41277701
[6S]5-methyltetrahydrofolate or folic acid supplementation and absorption and initial elimination of folate in young and middle-aged adults. PMID: 16151461

Dosing Guidance

Individual dose requirements for Folate (Quatrefolic 6S-5-MTHF) vary based on health goals, body weight, and existing dietary intake. A qualified healthcare provider can help you determine an appropriate amount for you.

Frequently Asked Questions

Which form of Folate (Quatrefolic 6S-5-MTHF) is in our formulary?
Our formulary carries a single form of Folate (Quatrefolic 6S-5-MTHF). Focus on products that specify the form on the label — not all forms are equally absorbed by the body.
How much Folate (Quatrefolic 6S-5-MTHF) should I take?
Dosing for Folate (Quatrefolic 6S-5-MTHF) varies based on the specific form, your health goals, and individual factors. Consult a qualified healthcare provider for personalized guidance.
What does Folate (Quatrefolic 6S-5-MTHF) support?
Folate (Quatrefolic 6S-5-MTHF) is commonly used to support vitamin. Research suggests it plays a role in several physiological pathways. As with all supplements, these statements have not been evaluated by the Food and Drug Administration and Folate (Quatrefolic 6S-5-MTHF) is not intended to diagnose, treat, cure, or prevent any disease.
Is Folate (Quatrefolic 6S-5-MTHF) safe?
Folate (Quatrefolic 6S-5-MTHF) is generally well-tolerated when taken at research-supported doses. As with any supplement, individual responses vary. Consult a qualified healthcare provider before use, especially if you are pregnant, nursing, have a medical condition, or take medications. These statements have not been evaluated by the Food and Drug Administration.

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References

  1. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. PubMed DOI
  2. Comparative Analysis of Treatment With Folate Forms in Clinical Practice. PubMed DOI
  3. [6S]5-methyltetrahydrofolate or folic acid supplementation and absorption and initial elimination of folate in young and middle-aged adults. PubMed DOI

FormulaForge formulates and sells supplements containing the ingredients discussed on this page. Our formulary recommendations are based on peer-reviewed bioavailability research. All cited studies are independently verifiable.