Ashwagandha (Withania somnifera) Root Extract

Ashwagandha (Withania somnifera) Root Extract is a Botanical supplement available in 1 form.

Not all forms of Ashwagandha (Withania somnifera) Root Extract are equal. The form you choose determines how much Ashwagandha (Withania somnifera) Root Extract actually reaches your tissues, and the difference between the best and worst forms can be substantial. FormulaForge ranks every form by how well it absorbs and how strongly the published research supports it, giving you an evidence-based guide for choosing wisely.

Ashwagandha Extract (5% Withanolides) (Mapped Form) has a bioavailability rating of good absorption.

Here is a detailed summary of Ashwagandha Extract (standardized to 5% Withanolides) based on the latest clinical evidence, safety data, dosing, bioavailability, and research from 2023-2024:

Human crossover PK: per-gram withanolide absorption rose sharply with standardization grade, the 35% withanolide-glycoside extract reaching AUC roughly 118 to 268-fold higher than 2.5%, 5%, and 10% extracts. PMID: 40792075

Human crossover PK: a 35% withanolide-glycoside extract was roughly 280-fold more bioavailable per mg than a 2.5% withanolide extract, quantifying the standardized-vs-unstandardized gap. PMID: 38144272

Human RCT: a high-concentration full-spectrum ashwagandha root extract (300 mg twice daily for 60 days) significantly reduced perceived-stress scores and serum cortisol versus placebo. PMID: 23439798

Multiple forms of Ashwagandha (Withania somnifera) Root Extract are available. Start by comparing form ratings — Preferred Forms reflect the strongest bioavailability evidence, and higher-absorption forms deliver more active compound per dose unit.

The appropriate form depends on your individual goals and your healthcare provider’s recommendations. Consult a qualified professional before selecting a supplement form.

Individual dose requirements vary based on health goals, body weight, and existing nutrient intake. Your healthcare provider can help you determine an appropriate amount of Ashwagandha (Withania somnifera) Root Extract for you.

Side Effects: Consult your healthcare provider regarding tolerability, particularly at higher doses.

These statements are based on structure/function research and have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before starting or changing a supplement regimen.

The following studies and findings inform FormulaForge classifications for Ashwagandha (Withania somnifera) Root Extract:

Human crossover PK: per-gram withanolide absorption rose sharply with standardization grade, the 35% withanolide-glycoside extract reaching AUC roughly 118 to 268-fold higher than 2.5%, 5%, and 10% extracts. PMID: 40792075

Human crossover PK: a 35% withanolide-glycoside extract was roughly 280-fold more bioavailable per mg than a 2.5% withanolide extract, quantifying the standardized-vs-unstandardized gap. PMID: 38144272

Human RCT: a high-concentration full-spectrum ashwagandha root extract (300 mg twice daily for 60 days) significantly reduced perceived-stress scores and serum cortisol versus placebo. PMID: 23439798

Human RCT: a full-spectrum ashwagandha root extract (300 mg twice daily for 10 weeks) significantly shortened sleep onset latency and improved sleep efficiency versus placebo. PMID: 31728244