ByDr. Brennan Commerford, D.C.·Last reviewed: July 2026
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Vitamin K2 (as Menaquinone-7): verification pending

We’re confirming the science for this compound before we publish a form ranking. Our team reviews every ranked page against peer-reviewed absorption data — this one is still under review, so we are not showing a score yet.

Check back soon. Rankings are reviewed by Dr. Brennan Commerford, D.C.

References

  1. Review: Postprandial serum MK-7 concentrations reported 10-fold higher than K1 (phylloquinone). K1 primarily retained in liver for coagulation; MK-7 redistributes to extrahepatic tissues (bone, vasculature) due to longer circulating half-life. Long-chain menaquinones detectable up to 96 hours vs 8-24 hours for K1. PubMed
  2. Crossover RCT (n=5 healthy women): single dose MK-4 (420μg) was undetectable in serum at all time points; MK-7 (420μg) reached peak serum concentration at 6 hours and was detectable up to 48 hours post-intake. Consecutive daily MK-7 produced significant cumulative serum accumulation; MK-4 showed none. PubMed
  3. Healthy volunteers: natto-derived MK-7 accumulated 7-8 fold higher serum levels than synthetic vitamin K1 (phylloquinone) during prolonged supplementation. MK-7 induced more complete carboxylation of osteocalcin (extrahepatic tissue marker) vs K1. Both absorbed with peak at 4 hours; MK-7 sustained versus K1 rapid decline. PubMed

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.