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L-Citrulline: verification pending
We’re confirming the science for this compound before we publish a form ranking. Our team reviews every ranked page against peer-reviewed absorption data — this one is still under review, so we are not showing a score yet.
Check back soon. Rankings are reviewed by Dr. Brennan Commerford, D.C.
References
- A 2022 randomized controlled trial in postmenopausal women with hypertension found that 4 weeks of L-citrulline supplementation increased L-arginine availability and was associated with improved blood-vessel dilation response in this population; because the study population had diagnosed hypertension, this finding should be read as preliminary support for vascular/endothelial function in general use, not as a blood-pressure management claim. PubMed
- A 2018 review reported that L-citrulline supplementation raises circulating L-arginine levels and supports nitric oxide synthesis more effectively than direct L-arginine supplementation, supporting normal vascular function. PubMed
- In a randomized crossover study, L-citrulline raised plasma arginine to a similar magnitude as direct arginine supplementation while additionally increasing plasma citrulline, demonstrating citrulline as an effective arginine precursor. PubMed
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.