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Huperzine A: verification pending
We’re confirming the science for this compound before we publish a form ranking. Our team reviews every ranked page against peer-reviewed absorption data — this one is still under review, so we are not showing a score yet.
Check back soon. Rankings are reviewed by Dr. Brennan Commerford, D.C.
Interaction & safety note
Huperzine A is an acetylcholinesterase inhibitor and can interact with cholinergic medications and other drugs that affect acetylcholine. Talk to your physician before use, especially if you take medication for Alzheimer's disease, glaucoma, or a heart condition.
References
- A 2016 population pharmacokinetic study in elderly subjects characterized how huperzine A, an acetylcholinesterase inhibitor that prolongs the action of the neurotransmitter acetylcholine, is absorbed and cleared in older adults, finding that age significantly affects its clearance rate. PubMed
- A 2006 review reported that huperzine A, an acetylcholinesterase inhibitor from Huperzia serrata, crosses the blood-brain barrier and has high oral bioavailability, and summarized clinical research in which it was studied for supporting memory in older adults. PubMed
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.