ByDr. Brennan Commerford, D.C.·Last reviewed: July 2026
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Folate (as Quatrefolic®): verification pending

We’re confirming the science for this compound before we publish a form ranking. Our team reviews every ranked page against peer-reviewed absorption data — this one is still under review, so we are not showing a score yet.

Check back soon. Rankings are reviewed by Dr. Brennan Commerford, D.C.

References

  1. 5-MTHF supplementation bypasses MTHFR polymorphism, achieving equivalent folate status regardless of genotype PubMed
  2. MTHFR C677T homozygotes show 70% reduced capacity to convert folic acid to active 5-MTHF PubMed
  3. Population frequency of MTHFR C677T homozygosity ranges 10-15%, supporting clinical relevance of methylfolate supplementation PubMed
  4. Folic acid and 5-MTHF show equivalent bioavailability and plasma folate response in MTHFR wild-type individuals PubMed

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.